By Thierry Burnouf, Yu-Wen Wu, Josephine Cheng, Sharon Wu, Karen Chan, Leo Liao, Xisheng Cao, and Bin Wang

Purification of IgG (hyperimmune immunoglobulins) from plasma is a time-consuming process with many steps. With a growing number of therapeutic applications for plasma IgG, and persistent shortage around the globe, optimization of the purification process to increase yield and productivity, while maintaining a cost-efficient process, is essential.

In this white paper, we present the results from our collaboration with Taipei Medical University to develop and evaluate the reliability and consistency of various new steps to purify plasma-derived IgG. The process has since been modernized and optimized using a series of innovative technologies, capable of ensuring contaminant removal and virus safety.

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