Portugal: Peritoneal protein loss (PPL) quantification may be expressed in accordance with a timely collection (24-h measurement or 4-h PET assessment) and as a concentration.

A recent study in the Karger journal Blood Purification has found that measurements of a 24-h sample might be closer to the clinical status and prognosis of the patient, indicating opportunities for therapy intervention. Further, the researchers found that the quantification of PET protein loss should be regarded as a marker of peritoneal membrane intrinsic permeability.

Guedes A. Malho and colleagues from Portugal aimed to compare the quantification methods of 24-h and 4-h collections. The study included 81 prevalent peritoneal dialysis patients. Registration of demographics and clinical and bioelectrical impedance features was done. Measurement of PPL (4-h PET and 24-h results) was done and peritoneal protein clearance was calculated. A linear regression model was performed.

Based on the study, the researchers found the following:

The researchers wrote, "different methods sign different pathophysiological pathways. Quantification of PET protein loss should be regarded as a marker of peritoneal membrane intrinsic permeability."

"Measurements of a 24-h sample might be closer to patients' clinical status and prognosis, signalizing opportunities for therapy intervention," they conclude.

The study titled, "Protein Loss in Peritoneal Effluent: Different Meaning for 24-h versus PET Samples," was published in the journal Blood Purification.

Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751